Water → 1-(2,4,6-Trichlorophenyl)-3-acetylamino-4-bromo-5-oxo-2-pyrazoline

HRID 1163975Notes

Reaction equation

HRID 1163975 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([NH:16][C:17](=[O:19])[CH3:18])=[N:11]1.[Br:20]Br.O>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]([Br:20])[C:12]([NH:16][C:17](=[O:19])[CH3:18])=[N:11]1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 4497701N-[5-oxo-1-(2,4,6-trichlorophenyl)-2-pyrazolin-3-yl]acetamide

Product 1

HCID 129947761-(2,4,6-Trichlorophenyl)-3-acetylamino-4-bromo-5-oxo-2-pyrazolineYield 84%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

54.5 g (0.17 mol) of 1-(2,4,6-trichlorophenyl)-3-acetylamino-5-oxo-2-pyrazoline was dissolved in 300 ml of acetic acid, to which there was then gradually added dropwise 27.2 g (0.17 mol) of bromine. After stirring for 1 hour, the reaction mixture was poured into 900 ml of water and the crystals thus-separated were collected by filtration to obtain 57 g (84% yield) of 1-(2,4,6-trichlorophenyl)-3-acetylamino-4-bromo-5-oxo-2-pyrazoline.

Workup

  1. customthe crystals thus-separated
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-f27919ff7b844476bd7fdfdb74a61449
Source dataset
uspto-grants-1983_01
Patent number
US04367282

Reaction notes

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