Dimethyl Sulfate → HCID 20513418, compound

HRID 1164003Notes

Reaction equation

HRID 1164003 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:18]=[CH:17][C:7]([O:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]([CH3:16])[C:14]=2[OH:15])=[CH:6][CH:5]=1.S(OC)(O[CH3:23])(=O)=O>O>[CH3:23][O:15][C:14]1[C:13]([CH3:16])=[CH:12][CH:11]=[CH:10][C:9]=1[O:8][C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 20513446HCID 20513446, compound

Product 1

HCID 20513418HCID 20513418, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An aqueous solution (25 ml) of potassium hydroxide (7.5 g) was added to a mixture of 6-(4-chlorophenoxy)-o-cresol (10.5 g) and dimethyl sulfate (8.6 ml) with stirring at room temperature, and refluxed under heating for an hour. After cooling, water was added to the reaction mixture and extracted with n-hexane. The extract was washed with water, dried over magnesium sulfate and evaporated to give oily 4-chlorophenyl 2-methoxy-3-methylphenyl ether (10.7 g).

Workup

  1. temperaturerefluxed
  2. temperatureunder heating for an hour
  3. temperatureAfter cooling
  4. extractionextracted with n-hexane
  5. washThe extract was washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

Sources & evidence

ORD record
ord-9ea520f3ecce454ebd3ad43819dfd966
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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