Hydrogen iodide → HCID 13066682, compound

Participants

Reaction Steps

48% Hydriodic acid (40 ml) was added dropwise to a solution of 2-[2-methoxy-3-(4-chlorophenoxy)phenyl]acetic acid (6.7 g) in acetic anhydride (20 ml) with stirring under ice-cooling in 5 minutes, and the mixture was refluxed under heating for 20 minutes. The reaction mixture was poured into an ice-water containing a small amount of sodium hydrogen sulfite and allowed to stand. The precipitating crystals were collected by filtration, washed with water, dried and then recrystallized from a mixture of benzene and n-hexane to give 2-[2-hydroxy-3-(4-chlorophenoxy)phenyl]acetic acid (4.4 g). mp 100°-102° C.

Provenance & Evidence