2-[2-Hydroxy-3-(3-chlorophenoxy)phenyl]acetic acid → 7-(3-Chlorophenoxy)-2,3-dihydrobenzofuran-2-one

HRID 1164015Notes

Reaction equation

HRID 1164015 reaction equation
O[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([OH:19])=[O:18]>C(OC(=O)C)(=O)C>[Cl:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][C:7]1[C:2]2[O:19][C:17](=[O:18])[CH2:16][C:3]=2[CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 130666832-[2-Hydroxy-3-(3-chlorophenoxy)phenyl]acetic acid

Product 1

HCID 130667097-(3-Chlorophenoxy)-2,3-dihydrobenzofuran-2-oneYield 88.2%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 2-[2-hydroxy-3-(3-chlorophenoxy)phenyl]acetic acid (2 g) in acetic anhydride (10 ml) was treated in a similar manner to that of Example 6-(7) to give 7-(3-chlorophenoxy)-2,3-dihydrobenzofuran-2-one (1.65 g). mp 105°-106° C.

Sources & evidence

ORD record
ord-ef74a010426a430f8e4b0c6998e0d93d
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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