Sodium borohydride → HCID 54361690, compound

HRID 1164025Notes

Reaction equation

HRID 1164025 reaction equation
[CH3:1][O:2][C:3]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[BH4-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][OH:6]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 20513429HCID 20513429, compound

Product 1

HCID 54361690HCID 54361690, compoundYield 55.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-methoxy-3-(2-chlorophenoxy)benzaldehyde (5.0 g) in methanol (50 ml) and sodium borohydride (720 mg) were treated in a similar manner to that of Example 3-(5). The resultant residue was subjected to column chromatography on silica gel (100 g) and eluted with a mixture of benzene and ethyl acetate (10:1) to give crystalline 2-methoxy-3-(2-chlorophenoxy)benzyl alcohol (2.8 g).

Workup

  1. washeluted with a mixture of benzene and ethyl acetate (10:1)

Sources & evidence

ORD record
ord-34432ea7ac0d4f40b3d38f003252ecb6
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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