Phthalic Anhydride → HCID 20513487, compound

HRID 1164035Notes

Reaction equation

HRID 1164035 reaction equation
O[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:16]([C:18]([OH:20])=[O:19])[NH2:17].[C:21]1(=O)[O:26][C:24](=[O:25])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12>>[C:21]1(=[O:26])[N:17]([CH:16]2[C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([O:8][C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[CH3:15])[C:2]=3[O:20][C:18]2=[O:19])[C:24](=[O:25])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12

Participants

3

Reactant 2

HCID 6811Phthalic AnhydrideHCID 130666882-[2-Hydroxy-3-(o-tolyloxy)phenyl]glycine

Product 1

HCID 20513487HCID 20513487, compoundYield 12.1%

Conditions

Temperature
200 °C

Procedure

A mixture of 2-[2-hydroxy-3-(o-tolyloxy)phenyl]glycine (10.6 g) and phthalic anhydride (5.7 g) was heated in an oil bath (200° C.) for 5 minutes. After cooling, the reaction mixture was subjected to column chromatography on silica gel (280 g) and eluted with benzene to give 3-phthalimido-7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one (1.8 g). mp 168°-170° C.

Workup

  1. temperatureAfter cooling
  2. washeluted with benzene

Sources & evidence

ORD record
ord-5916fb6a8e63452ca543add34e1037f5
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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