Hydrochloric Acid → HCID 20513478, compound

Participants

Reaction Steps

A mixture of ethyl 2-cyano-2-[2-methoxy-3-(o-tolyloxy)phenyl]butyrate (4.1 g), conc. hydrochloric acid (20 ml) and acetic acid (40 ml) was refluxed under heating for 48 hours. The reaction mixture was evaporated, and 10% aqueous sodium hydroxide and ethanol were added to the residue. The mixture was refluxed under heating for 30 minutes and then evaporated. Water was added to the residue, washed with diethyl ether, acidified with conc. hydrochloric acid and extracted with diethyl ether. The extract was washed with water, dried and evaporated to give oily 2-[2-methoxy-3-(o-tolyloxy)phenyl]butyric acid (2.2 g).

Provenance & Evidence