Potassium Hydroxide → HCID 20513471, compound

HRID 1164051Notes

Reaction equation

HRID 1164051 reaction equation
C([C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:13]=1[O:26][CH3:27])([CH2:9][CH2:10][CH3:11])[C:4]([O:6]CC)=[O:5])#N.[OH-].[K+]>C(O)C.O>[CH3:27][O:26][C:13]1[C:14]([O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])=[CH:15][CH:16]=[CH:17][C:12]=1[CH:3]([CH2:9][CH2:10][CH3:11])[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 20513409Ethyl 2-cyano-2-[2-methoxy-3-(2-chlorophenoxy)phenyl]valerate

Product 1

HCID 20513471HCID 20513471, compoundYield 62.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of ethyl 2-cyano-2-[2-methoxy-3-(2-chlorophenoxy)phenyl]valerate (7 g) and potassium hydroxide (5 g) in ethanol (80 ml) and water (40 ml) was treated in a similar manner to that of Example 14-(7) to give oily 2-[2-methoxy-3-(2-chlorophenoxy)phenyl]valeric acid (3.8 g).

Workup

  1. additionwas treated in a similar manner to that of Example 14-(7)

Sources & evidence

ORD record
ord-8c85b17af85846f2be77b10c20527463
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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