Sodium Cyanide → HCID 20513452, compound

HRID 1164058Notes

Reaction equation

HRID 1164058 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH2:9]Br)=[CH:7][CH:6]=[CH:5][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C-:18]#[N:19].[Na+]>CS(C)=O>[CH3:1][O:2][C:3]1[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][CH:6]=[CH:7][C:8]=1[CH2:9][C:18]#[N:19]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 20513501Phenyl 2-methoxy-3-bromomethylphenyl ether

Product 1

HCID 20513452HCID 20513452, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of phenyl 2-methoxy-3-bromomethylphenyl ether (8.5 g) in dimethyl sulfoxide (30 ml) and powdered sodium cyanide (1.45 g) were treated in a similar manner to that of Example 14-(4) to give oily 2-(2-methoxy-3-phenoxyphenyl)acetonitrile (6.6 g).

Sources & evidence

ORD record
ord-4bfff4c2960b4165bd1048f7257809e1
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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