Potassium Hydroxide → HCID 20513406, compound

HRID 1164073Notes

Reaction equation

HRID 1164073 reaction equation
[C:1]([C:3]([C:10]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[CH:13]=[CH:12][C:11]=1[O:24][CH3:25])(C)[C:4]([O:6]CC)=[O:5])#N.[OH-].[K+]>O.C(O)C>[CH3:25][O:24][C:11]1[CH:12]=[CH:13][C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])=[CH:15][C:10]=1[CH:3]([CH3:1])[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 20513497HCID 20513497, compound

Product 1

HCID 20513406HCID 20513406, compoundYield 68.2%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of ethyl 2-cyano-2-[2-methoxy-5-(2-chlorophenoxy)phenyl]propionate (5.5 g) and potassium hydroxide (4.3 g) in water 40 ml and ethanol (80 ml) was treated in a similar manner to that of Example 14-(7) to give oily 2-[2-methoxy-5-(2-chlorophenoxy)phenyl]propionic acid (3.2 g).

Workup

  1. additionwas treated in a similar manner to that of Example 14-(7)

Sources & evidence

ORD record
ord-0d457311be3e4c2487117847f7493c7e
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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