Potassium Hydroxide → 2-[2-Hydroxy-3-(2-chlorophenylthio)phenyl]acetic acid

HRID 1164084Notes

Reaction equation

HRID 1164084 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[C:17]2[O:16][C:15](=[O:18])[CH2:14][C:13]=2[CH:12]=[CH:11][CH:10]=1.[OH-:19].[K+]>CO>[OH:16][C:17]1[C:9]([S:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])=[CH:10][CH:11]=[CH:12][C:13]=1[CH2:14][C:15]([OH:18])=[O:19]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 130667157-(2-Chlorophenylthio)-2,3-dihydrobenzofuran-2-one

Product 1

HCID 130666902-[2-Hydroxy-3-(2-chlorophenylthio)phenyl]acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-(2-Chlorophenylthio)-2,3-dihydrobenzofuran-2-one (0.2 g) was added to a solution of potassium hydroxide in methanol, and the mixture was stirred under warming to give 2-[2-hydroxy-3-(2-chlorophenylthio)phenyl]acetic acid (0.2 g), mp. 91°-93° C.

Workup

  1. temperatureunder warming

Sources & evidence

ORD record
ord-9c368c84a1f84b2697b645891035f0c7
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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