Acetic Anhydride → HCID 20513433, compound

HRID 1164103Notes

Reaction equation

HRID 1164103 reaction equation
C(OC(=O)C)(=O)C.O[C:9]1[C:14]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])=[CH:13][CH:12]=[CH:11][C:10]=1[CH:23]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:24]([OH:26])=[O:25]>>[CH2:27]([CH:23]1[C:10]2[CH:11]=[CH:12][CH:13]=[C:14]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:9]=2[O:25][C:24]1=[O:26])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20513474HCID 20513474, compound

Product 1

HCID 20513433HCID 20513433, compoundYield 73.5%

Procedure

Acetic anhydride (5 ml) was added to 2-[2-hydroxy-3-(o-tolyloxy)phenyl]-n-nonanoic acid (4.3 g), and the mixture was refluxed under heating for 10 minutes and evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 60 g, benzene) to give 3-(n-heptyl)-7-(o-tolyloxy)-2,3-dihydrobenzofuran-2-one (3.0 g).

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 10 minutes
  3. customevaporated under reduced pressure
  4. customThe residue was purified by column chromatography (silica gel 60 g, benzene)

Sources & evidence

ORD record
ord-fb04645f4ac34575ac460838686c738c
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

Loading…