反应详情

A solution of potassium hydroxide (5.8 g) in water (30 ml) was added dropwise to a mixture of 2-hydroxy-3-(o-tolylthio)benzyl alcohol (8.3 g) and dimethyl sulfate (8.5 g) in 10 minutes at temperature below 60° C. with stirring, and the mixture was stirred at the same temperature for 10 minutes. The reaction mixture was treated in a similar manner to that of Example 21-(4). The resultant oily residue was purified by column chromatography (silica gel 150 g, benzene) to give oily 2-methoxy-3-(o-tolylthio)benzyl alcohol (8.5 g).

1. stirringthe mixture was stirred at the same temperature for 10 minutes
2. additionThe reaction mixture was treated in a similar manner to that of Example 21-(4)
3. customThe resultant oily residue was purified by column chromatography (silica gel 150 g, benzene)