HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-[2-Hydroxy-3-(o-tolylthio)phenyl]propionic acid | HCID 13139428 | — |
| Product | 3-Methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one | HCID 20513424 | 74.7% |
Reaction Steps
A mixture of 2-[2-hydroxy-3-(o-tolylthio)phenyl]propionic acid (2.0 g) and acetic anhydride (5 ml) was refluxed under heating and evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 30 g, benzene) to give 3-methyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04367238 |
| Source dataset | uspto-grants-1983_01 |
| ORD ID | ord-5fba9a8a67a54bcf9783b8989b6d6d1a |
| Source note | uspto-grants-1983_01 |