Pyridine → HCID 20513500, compound

HRID 1164116Notes

Reaction equation

HRID 1164116 reaction equation
N1C=CC=CC=1.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21].[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[F:7])(=[O:24])[CH3:23]

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 20513430HCID 20513430, compound

Product 1

HCID 20513500HCID 20513500, compound

Procedure

Pyridine (1 ml) was added to a solution of 2-(2-fluorophenylthio)phenol (9.4 g) in acetic anhydride (10 ml), and the mixture was stirred at room temperature for 30 minutes. The excess of acetic anhydride was distilled off under reduced pressure, and the resultant oily residue was dissolved in diethyl ether. The ether solution was washed with 10% hydrochloric acid and water in turn, dried and evaporated under reduced pressure to give oily 2-fluorophenyl 2-acetoxyphenyl thioether (11.2 g).

Workup

  1. distillationThe excess of acetic anhydride was distilled off under reduced pressure
  2. dissolutionthe resultant oily residue was dissolved in diethyl ether
  3. washThe ether solution was washed with 10% hydrochloric acid and water in turn
  4. customdried
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-b0fee0e01f7a4be49337e2c3349b7338
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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