3-n-Hexyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one → 2-[2-Hydroxy-3-(o-tolylthio)phenyl]octanoic acid

HRID 1164124Notes

Reaction equation

HRID 1164124 reaction equation
[CH2:1]([CH:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[C:15]([S:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[CH3:23])[C:10]=2[O:9][C:8]1=[O:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[OH-:25].[K+].CO>>[OH:9][C:10]1[C:15]([S:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])=[CH:14][CH:13]=[CH:12][C:11]=1[CH:7]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[C:8]([OH:24])=[O:25]

Participants

3

Reactant 2

HCID 205134193-n-Hexyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-oneHCID 23689386Potassium hydroxide methanol

Product 1

HCID 130666982-[2-Hydroxy-3-(o-tolylthio)phenyl]octanoic acid

Procedure

3-n-Hexyl-7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one was hydrolyzed by treating with potassium hydroxide-methanol to give 2-[2-hydroxy-3-(o-tolylthio)phenyl]octanoic acid, mp. 90°-91° C.

Sources & evidence

ORD record
ord-6dda6ee0cd364d61979b189d0b6b4796
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

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