7-(o-Tolylthio)-2,3-dihydrobenzofuran-2-one → 2-[2-Hydroxy-3-(o-tolylthio)phenyl]acetic acid

HRID 1164126Notes

Reaction equation

HRID 1164126 reaction equation
[C:1]1([CH3:18])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][C:8]1[C:16]2[O:15][C:14](=[O:17])[CH2:13][C:12]=2[CH:11]=[CH:10][CH:9]=1.[OH-:19].[K+].CO>>[OH:15][C:16]1[C:8]([S:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:18])=[CH:9][CH:10]=[CH:11][C:12]=1[CH2:13][C:14]([OH:19])=[O:17]

Participants

3

Reactant 2

HCID 130667197-(o-Tolylthio)-2,3-dihydrobenzofuran-2-oneHCID 23689386Potassium hydroxide methanol

Product 1

HCID 130666992-[2-Hydroxy-3-(o-tolylthio)phenyl]acetic acid

Procedure

Thus obtained 7-(o-tolylthio)-2,3-dihydrobenzofuran-2-one was hydrolyzed by treating with potassium hydroxide-methanol to give 2-[2-hydroxy-3-(o-tolylthio)phenyl]acetic acid, mp. 96°-97° C.

Sources & evidence

ORD record
ord-08558a11ac4b449981082409bdb17813
Source dataset
uspto-grants-1983_01
Patent number
US04367238

Reaction notes

Loading…