1-(3-Chlorophenyl)piperazine → HCID 86738729, compound

HRID 1164133Notes

Reaction equation

HRID 1164133 reaction equation
Br[CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][S:6][C:5]1=[O:10].[Cl:11][C:12]1[CH:13]=[C:14]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH:15]=[CH:16][CH:17]=1>>[ClH:11].[Cl:11][C:12]1[CH:13]=[C:14]([N:18]2[CH2:23][CH2:22][N:21]([CH2:2][CH2:3][N:4]3[C:8](=[O:9])[CH2:7][S:6][C:5]3=[O:10])[CH2:20][CH2:19]2)[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 16392506HCID 16392506, compound

Product 1

HCID 86738729HCID 86738729, compound

Procedure

Reaction of 3-(2-bromoethyl)-2,4-thiazolidinedione with 1-(3-chlorophenyl)piperazine according to the procedure of Example 1(c) affords 3-[2-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]ETHYL]-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE, m.p. 210°-213° C., from ethanol (43% yield).

Sources & evidence

ORD record
ord-42dd7f47db864f7792ced5b1efec7eaf
Source dataset
uspto-grants-1983_01
Patent number
US04367335

Reaction notes

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