Nitric Acid → 3-Nitro-5,6,7,8-tetrahydronaphthalen-2-ol

Beteiligte Stoffe

Reaktionsschritte

To a solution of 5,6,7,8-tetrahydro-2-naphthol (44 g) in 300 ml of acetic acid was added dropwise fuming nitric acid (12 ml in 12 ml of acetic acid) over a period of 30 minutes. The reaction mixture was then stirred for an additional 5 hours at room temperature. After evaporation of the solvent, the crude product was purified by column chromatography (silica gel) to give 16 g of pure product, m.p. 88°-89° C.

Herkunft & Nachweise