Thionyl Chloride → HCID 20464099, compound

HRID 1164202Notes

Reaction equation

HRID 1164202 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][C:12]([OH:14])=O)([O-:3])=[O:2].S(Cl)([Cl:17])=O>C(Cl)Cl>[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][CH2:11][C:12]([Cl:17])=[O:14])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 748183-(2-Nitrophenyl)propionic acid

Product 1

HCID 20464099HCID 20464099, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A stirred solution of 74.2 g (0.38 mole) of 3-(2-nitrophenyl)propionic acid and 53.6 g (0.45 mole) of thionyl chloride in 250 mL of methylene chloride was heated under reflux for 16 hours. The reaction mixture was concentrated under reduced pressure to give a residue, which was dissolved in 100 mL of methylene chloride. The solution was concentrated under reduced pressure, and the residue was subjected to high vacuum to give 3-(2-nitrophenyl)propionyl chloride as an oil.

Workup

  1. temperatureunder reflux for 16 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto give a residue, which
  4. concentrationThe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-40996680ab934594b1a175eaebd58dd9
Source dataset
uspto-grants-1983_01
Patent number
US04368205

Reaction notes

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