Glycol monoethyl ether → HCID 101835019, compound

Participants

Reaction Steps

55 g of sodium 2-chloro-5-nitrobenzenesulfonate was added to a sodium 2-ethoxyethylate solution prepared by adding 7.3 g of sodium hydride (14.6 g in the form of a 50% liquid paraffin suspension) to 300 ml of ethyl cellosolve. This reaction mixture was stirred for 30 minutes while maintaining the temperature at 80° to 85° C. After completion of the reaction, insolubles were filtered off, and 150 ml of ethyl cellosolve was distilled out of the filtrate. 300 ml of isopropyl alcohol was added to the concentrate and cooled with ice. Crystals thus formed were collected by filtration, washed with 100 ml of isopropyl alcohol, and air-dried. Yield: 33 g; m.p. above 250° C.

Provenance & Evidence