Hydrochloric Acid → HCID 70523952, compound

Participants

Reaction Steps

To 200 cc of a chloroform were added 22.28 g (0.04 mole) of 5-octadecyl succinimide-2-phenyl-3-aminoindole and 9.1 g (0.01 mole) of m-nitrobenzene sulfonic acid chloride, and to the mixture solution were dropwise added 3.24 g of pyridine under nitrogen gas flow, and stirred over a period of 4 hours, and the thus deposited Precipitate was filtered, whereby 18 g of crude crystals of 5-octadecyl succinimide-2-phenyl-3-{N-(3-nitrobenzene sulfonyl)amino}indole were obtained. 16 g of the obtained crystals were added to 140 ml of acetone, and to the solution were added 3.5 g of zinc powder and 7 ml of hydrochloric acid at a temperature of from 15° to 20° C. and, keeping the temperature, further added alternately 5.7 g of zinc powder and 15 ml of hydrochloric acid. This was stirred for 30 minutes after the addition and was added with stirring to 100 ml of water to deposit crystals. The crystals were centrifugally separated, stirred, washed, refined by column chromatography, and then dried, thereby obtaining 12.8 g of an objective product.

Provenance & Evidence