Diethyl Ether → HCID 20511711, compound

Participants

Reaction Steps

15.9 g. of p-benzyloxybenzoyl chloride, 500 ml. of absolute diethyl ether and 6.3 ml. of 2-pyrrolidinone are treated with 13.4 ml. of triethylamine at 0° C. to 10° C. while stirring. The mixture is stirred at reflux for 9 hours, then cooled down and treated at 0° C. with cold water and ethyl acetate. The organic phase is washed with water, dried over sodium sulfate and evaporated. The residue is triturated with diethyl ether and the insoluble constituents are chromatographed over silica gel (particle size 0.2-0.5 mm). The constituents elutable with methylene chloride are triturated with diethyl ether. The insoluble constituents are filtered off and there is obtained 1-(p-benzyloxybenzoyl)-2-pyrrolidinone, having a melting point of 115°-117° C.

Provenance & Evidence