HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methane → Aniracetam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-p-Anisamidobutyric acid | HCID 155723 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Aniracetam | HCID 2196 | — |
Reaction Steps
20.0 g. of 4-(p-methoxybenzoylamino)butyric acid, 50 ml. of toluene and 9.2 ml. of thionyl chloride are heated at reflux for 2 hours and then the mixture is treated with decolorizing charcoal and evaporated. The residue is dissolved in methylene chloride and chromatographed over neutral aluminum oxide. The 1-(p-methoxybenzoyl)-2-pyrrolidinone, which is eluted with methylene chloride, is recrystallized from alcohol and has a melting point of 119°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04369139 |
| Source dataset | uspto-grants-1983_01 |
| ORD ID | ord-594cd5b101394f6caa817b19323f7ec7 |
| Source note | uspto-grants-1983_01 |