HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(Chloromethyl)-4-fluoro-2-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-Fluoro-2-methylphenyl)methanol | HCID 3872017 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(Chloromethyl)-4-fluoro-2-methylbenzene | HCID 20511816 | 100% |
Reaction Steps
To 14.3 parts of thionyl chloride is added dropwise a solution of 14 parts of 4-fluoro-2-methylbenzenemethanol and 0.9 parts of N,N-dimethylformamide in 45 parts of methylbenzene while cooling in ice-water. Then there are added 135 parts of methylbenzene and stirring is continued for 1 hour at room temperature. The reaction mixture is evaporated, yielding 17 parts (100%) of 1-(chloromethyl)-4-fluoro-2-methylbenzene as a residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04369184 |
| Source dataset | uspto-grants-1983_01 |
| ORD ID | ord-d91ea89eefb84bd78f5f2ceb30f9874d |
| Source note | uspto-grants-1983_01 |