Thionyl Chloride → HCID 20511807, compound

Participants

Reaction Steps

To a stirred and refluxing mixture of 21 parts of 4-(5-chloro-2-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-piperidinecarboxylic acid and 270 parts of benzene are added dropwise 36 parts of thionyl chloride. Upon completion, the whole is stirred and refluxed for 4 hours. The reaction mixture is evaporated and the residue is washed twice with methylbenzene, yielding 22 parts (100%) of 4-(5-chloro-2-methoxyphenyl)-1-(4-methylphenylsulfonyl)-4-piperidinecarbonyl chloride.

Provenance & Evidence