Methane → HCID 13094251, compound

Participants

Reaction Steps

A mixture of 36.5 parts of 4-(3-chloro-2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-piperidinecarbonyl chloride and 240 parts of ethanol is stirred and refluxed overnight. The reaction mixture is treated with activated charcoal while hot. The latter is filtered off and the product is allowed to crystallize from the filtrate by cooling spontaneously to room temperature. The product is filtered off and dried, yielding 33 parts (89.1%) of ethyl 4-(3-chloro-2-methylphenyl)-1-(4-methylphenylsulfonyl)-4-piperidinecarboxylate; mp. 134° C.

Provenance & Evidence