Piperidine-1-propanol → HCID 70516746, compound

Participants

Reaction Steps

To a stirred and refluxing mixture of 14 parts of 4-phenyl-4-piperidinecarbonyl chloride hydrochloride and 130 parts of methylbenzene are added dropwise 6.9 parts of 1-piperidinepropanol. Upon completion, stirring is continued overnight at reflux temperature. The methylbenzene-phase is decanted and the residual oil is boiled in a mixture of 2,2'-oxybispropane and ethanol. The precipitated product is filtered off and dried, yielding 14 parts of 3-(1-piperidinyl)-propyl 4-phenyl-4-piperidinecarboxylate dihydrochloride monohydrate; mp. 176.1° C.

Provenance & Evidence