Sodium borohydride → HCID 13094167, compound

Participants

Reaction Steps

To a stirred mixture of 4.5 parts of ethyl 1-[4-cyano-4-(2-pyridinyl)-1-cyclohexenyl]-4-phenyl-4-piperidinecarboxylate and 80 parts of ethanol are added portionwise 0.4 parts of sodium borohydride. Upon completion, stirring is continued first overnight at room temperature and further for 30 minutes at reflux. The reaction mixture is cooled and poured onto water. The product is extracted with dichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from 2-propanol, yielding 2 parts (35%) of ethyl 1-[4-cyano-4-(2-pyridinyl)cyclohexyl]-4-phenyl-4-piperidinecarboxylate; mp. 157.1° C.

Provenance & Evidence