反应详情

654 g (3 mol) of 4,5-dichloro-2-dichloromethylene-imidazole in a finely powdered form were added incrementally in the course of about one hour, to a mixture, which had been initially introduced, of 783 g (9 mol) of isopropylformamide and 162 g (9 mol) of water, while stirring and cooling slightly, whereupon the internal temperature rose to about 75° C. The reaction mixture was then heated to about 90°-110° C. for a further half hour. After cooling, the product was precipitated in water, filtered off, washed with water and dried. In this way, 566 g (85% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid isopropylamide with a melting point of 150° C. were obtained.

1. temperaturecooling slightly, whereupon the internal temperature
2. customrose to about 75° C
3. temperatureThe reaction mixture was then heated to about 90°-110° C. for a further half hour
4. temperatureAfter cooling
5. customthe product was precipitated in water
6. filtrationfiltered off
7. washwashed with water
8. customdried