HCID 40592955, compound → HCID 13190105, compound

Participants

Reaction Steps

Benzyl t-butyloxycarbonyl-L-valyl-D-isoglutaminate (7.5 g, 17.2 mmol) was catalytically hydrogenated in methanol (150 ml) using palladium black as a catalyst at room temperature for 6 hours. The catalyst was filtered and the solvent was evaporated. Petroleum ether was added to the residue. After trituration, the resulting powder was filtered. Reprecipitation from ethyl acetate/petroleum ether gave t-butyloxycarbonyl-L-valyl-D-isoglutamine (6.0 g). m.p. 89°-90° C. (dec.). [α]D23 +9.46° (C 0.5, DMF). Rf2 =0.32.

Provenance & Evidence