Tetrahydrofuran → HCID 13072168, compound

HRID 1164404Notes

Reaction equation

HRID 1164404 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[S:11]([NH2:14])(=[O:13])=[O:12])[CH:4]=[CH:3][CH:2]=1.[N:15]([C:18]1[N:23]=[C:22]([Cl:24])N=[C:20]([Cl:25])[N:19]=1)=[C:16]=[O:17].O1CCC[CH2:27]1>>[Cl:25][C:20]1[CH:27]=[C:22]([Cl:24])[N:23]=[C:18]([NH:15][C:16]([NH:14][S:11]([C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[C:10]=2[N:1]=[CH:2][CH:3]=[CH:4]3)(=[O:12])=[O:13])=[O:17])[N:19]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 944648-QuinolinesulfonamideHCID 130526242,4-Dichloro-6-isocyanato-1,3,5-triazine

Product 1

HCID 13072168HCID 13072168, compound

Procedure

To a stirred mixture of 1.8 g of 8-quinoline-sulfonamide in 15 ml tetrahydrofuran is added 2.3 g of 2-isocyanato-4,6-dichloro-1,3,5-triazine. This mixture is then heated to reflux temperature for 21/2 hours, then cooled to room temperature, filtered and the resultant filtrate triturated with hexanes and filtered to give 1.8 g solid, m.p. 198°-200°.

Workup

  1. temperatureThis mixture is then heated
  2. temperatureto reflux temperature for 21/2 hours
  3. filtrationfiltered
  4. customthe resultant filtrate triturated with hexanes
  5. filtrationfiltered

Sources & evidence

ORD record
ord-a278fc4382e741679ff5c1d5777868b3
Source dataset
uspto-grants-1983_01
Patent number
US04369320

Reaction notes

Loading…