Diazomethane → HCID 131712942, compound

Participants

Reaction Steps

In ether (6 ml) is dissolved diphenylmethyl 3-acetoxymethyl-7-hydroxyimino-3-cephem-4-carboxylate (349 mg), and under ice-cooling, an ethereal solution of diazomethane (1 ml, 0.77 mmol) is added. While the temperature raised gradually to room temperature, the mixture is stirred for an hour. The reaction mixture is then concentrated under reduced pressure and the residue is purified by thin-layer chromatography (developer: ethyl acetate-hexane=1:1) to give diphenylmethyl 3-acetoxymethyl-7-methoxyimino-3-cephem-4-carboxylate (75 mg).

Provenance & Evidence