Propylene Oxide → N-(beta-hydroxypropyl)-2,6-diethylaniline

HRID 1164450Notes

Reaction equation

[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH3:11])[C:4]=1[NH2:5])[CH3:2].[O:12]1[CH:14]([CH3:15])[CH2:13]1>>[OH:12][CH:14]([CH3:15])[CH2:13][NH:5][C:4]1[C:6]([CH2:10][CH3:11])=[CH:7][CH:8]=[CH:9][C:3]=1[CH2:1][CH3:2]

Participants

Reactant 2

HCID 6378Propylene Oxide

HCID 113692,6-Diethylaniline

Product 1

HCID 14304866N-(beta-hydroxypropyl)-2,6-diethylanilineYield 44.7%

Procedure

2,6-Diethylaniline is reacted with 1,2-epoxypropane as described in Example 3, Method (b), point (a) to obtain N-(β-hydroxypropyl)-2,6-diethylaniline with a yield of 44.7%; b.p.: 137°-145° C./1 mm Hg.

Sources & evidence

ORD record: ord-fe111a5bc27c44b3b9ef42f446b33004
Source dataset: uspto-grants-1983_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04369325

Reaction notes

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