Hydrochloric Acid → HCID 70531520, compound

Participants

Reaction Steps

A mixture of 8.0 g (21.1 mmoles) of 1,3-bis(2',6'-dimethylphenyl)-2-acetimino-imidazolidine-4-carboxylic acid, obtained as described in Example 63, and 200 ml of 1 n aqueous hydrochloric acid is heated on a steam bath for 3 hours, and then the mixture is allowed to stand at +5° C. overnight. Next day the separated precipitate is filtered off, washed with cold 1 n aqueous hydrochloric acid, and dried. 2.2 g of 1,3-bis(2',6'-dimethylphenyl)-2-imino-imidazolidine-4-carboxylic acid hydrochloride are obtained. This crude salt, melting at 288°-292° C., is sufficiently pure to subject it to further reactions. After recrystallization from 1 n aqueous hydrochloric acid the product melts at 316°-318° C. The aqueous acidic solution is concentrated to obtain further 4.4 g of the product (m.p.: 246°-256° C.), which is recrystallized from 1 n aqueous hydrochloric acid to obtain 2.9 g of a practically pure substance, melting at 292°-296° C. The pure compound is obtained with a total yield of 71.8%.

Provenance & Evidence