反应详情

4-(Methylaminomethyl)pyridine (5 g), dry chloroform (500 ml) and phenyl isocyanate (5 g) were stirred together at room temperature for 2 hours. The chloroform was then evaporated in vacuo and the resultant oil was redissolved in the minimum quantity of chloroform and chromatographed on a "Florisil" (Trade Mark) (100 g) column using chloroform containing gradually increasing quantities of methanol (up to 2.5%) as eluting solvent. Appropriate fractions (identified by t.l.c.) were combined and evaporated in vacuo to give 1-methyl-1-(4-pyridylmethyl)-3-phenylurea as an oil (8.0 g).

1. customThe chloroform was then evaporated in vacuo
2. dissolutionthe resultant oil was redissolved in the minimum quantity of chloroform
3. customchromatographed on a "Florisil" (Trade Mark) (100 g) column
4. washas eluting solvent
5. customevaporated in vacuo