反应详情

To a solution of methyl 2-oxo-5-chloro-3-benzothiazolineacetate (10 g) in dioxane (100 ml) was added dropwise bromine (2 ml) with stirring at 25°-30° C. during 40 minutes. After the stirring was continued at ambient temperature for 4 hours, precipitates in the resultant mixture were separated by filtration, washed with dioxane and diethylether and dried to give crystalline methyl 2-oxo-5-chloro-6-bromo-3-benzothiazolineacetate (8.38 g).

1. waitAfter the stirring was continued at ambient temperature for 4 hours
2. customprecipitates in the resultant mixture
3. customwere separated by filtration
4. washwashed with dioxane and diethylether
5. customdried