Sodium borohydride → HCID 88737033, compound

Participants

Reaction Steps

To a stirred solution of 7-[2-(2-amino-4-thiazolyl)glyoxyloylamino]-3-cephem-4-carboxylic acid (520 mg) in methanol (15 ml) was added sodium borohydride (100 mg) under ice-cooling, and stirred at the same temperature for 3 hours. Methanol was distilled off under reduced pressure from the reaction mixture, and the residue was dissolved in water (3 ml) and adjusted to pH 3 with 6 N-hydrochloric acid. The precipitates were collected by filtration, washed with water and dried over phosphorus pentoxide to give 7-[2-(2-amino-4-thiazolyl)-2-hydroxyacetamido]-3-cephem-4-carboxylic acid (290 mg).

Provenance & Evidence