反应详情

First 25.6 g (0.25 mole) of acetic anhydride and then 27.8 g (0.25 mole) of pivaloyl cyanide were introduced, in each case at room temperature, into 49.0 g (0.5 mole) of concentrated sulphuric acid already in the reaction vessel. After subsequently stirring the reaction mixture for 4 hours, 150 g of ice-water were added and the mixture was stirred thoroughly. The reaction product which precipitated was filtered off, washed with 100 ml of water and dried. 37.0 g (86.5% of theory) of trimethylpyruvic acid N-acetylamide were obtained as colorless, glistening flakes of melting point 82° to 84° C.; content according to determination by gas chromatography: >99%. No additional purification operations were required for further reactions.

1. stirringthe mixture was stirred thoroughly
2. customThe reaction product which precipitated
3. filtrationwas filtered off
4. washwashed with 100 ml of water
5. customdried