Potassium Carbonate → 5-Cholesten-3beta-ol benzoate

Participants

Reaction Steps

5-Cholesten-3β-ol-thionobenzoate (100 mg, 0.198 mmol), symdibromo-tetrachloroethane (323 mg, 0.991 mmol, and 4-methoxy-4'-dimethylaminodiphenyltelluride (0.7 mg, 0.00198 mmol) were stirred in a two phase system of chloroform (2 ml) and aqueous potassium carbonate (2.5 ml, 20%) at room temperature for 47 h. The reaction was worked up in exactly the same way as described above to afford 5-cholesten-3β-ol-benzoate (75 mg, 77%) m.p. 144°-145° (lit., 150°-151°). The i.r. spectrum was identical to that of an authentic sample.

Provenance & Evidence