Isonicotinamide → HCID 5108430, compound

Participants

Reaction Steps

The isonicotinamide of 2-amino-1-tetralone (1.14 g, 0.00429 mole) was placed in 12 ml of phosphorus oxychloride (phosphoryl chloride) and refluxed for 19 hours. The amide dissolved during this period of time. The excess reagent was removed under vacuum. The residue was treated with 12 ml of ethanol and 5 ml of water. The mixture was made basic with 10% KOH. On cooling, the product precipitated and was filtered to give 0.77 g (72% yield) of the oxazole, mp 129°-130° C. 1H NMR(δ, CDCl3): 3.10, 4H, A2B2 ; 7.3-7.9, 4H, m; 8.93, 4H, A2B2.

Provenance & Evidence