HCID 15728438, compound → HCID 19863044, compound

Participants

Reaction Steps

A solution of 0.70 g (0.002 mole) of 1-[4-chloro-2-fluoro-5-(1-methylethoxy)phenyl]-4-(3-fluoropropyl)-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one (prepared in Example 1) in 10 mL of concentrated sulfuric acid was stirred for 30 minutes at ambient temperature. The reaction mixture was poured into ice-water and the mixture was extracted with diethyl ether. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give 0.5 g of 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-(3-fluoropropyl)-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-one, which was used immediately in the next step of this reaction sequence.

Provenance & Evidence