反应详情

To a stirred solution of 20.0 g (0.14 mole) of 2-chloro-4-fluorophenol and 6.64 g (0.17 mole) of sodium hydroxide in 100 mL of water at 15° C. was added 17.7 g (0.19 mole) of methyl chloroformate. After complete addition, the mixture was stirred for 15 minutes then extracted with ethyl acetate. The organic phase was washed with a 1N sodium hydroxide solution, then dried over anhydrous magnesium sulfate. The dried extract was filtered, and the filtrate evaporated under reduced pressure to provide methyl (2-chloro-4-fluorophenyl) carbonate as a solid.

1. additionAfter complete addition
2. extractionthen extracted with ethyl acetate
3. washThe organic phase was washed with a 1N sodium hydroxide solution
4. dry with materialdried over anhydrous magnesium sulfate
5. extractionThe dried extract
6. filtrationwas filtered
7. customthe filtrate evaporated under reduced pressure