Acetone → p-Methoxyphenylpropionic acid

Participants

Reaction Steps

A solution comprising 15 parts of 2-chloro-1-(4'-methoxyphenyl)-1-propanone and 10 parts of propylene oxide in 500 parts of 10% v/v aqueous acetone was irradiated by means of a 450W mercury vapour lamp for 8 hours. The solvent was removed by distillation and the resulting acid was extracted with 5% w/v aqueous sodium hydroxide. Acidification yielded 9.5 parts of α-(4'-methoxyphenyl)-propionic acid, m.p. 55° C. to 57° C.

Provenance & Evidence