Perchloric Acid → HCID 14555943, compound

Participants

Reaction Steps

To the filtrate obtained in Example 1, section A and having a volume of 110 to 120 cm3, 100 cm3 of dichloromethane are added and the base is deliberated as described in Example 1. To the dichloromethane solution containing 19.0 g of base as determined by means of titration with perchloric acid, an equivalent quantity of L(+)-tartaric acid is added under stirring. The mixture is stirred for several hours, the (+)-base L(+)-tartrate precipitated is filtered and dried. 21.6 g (87.0%) of (+)-2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine L(+)-tartrate are obtained, m.p.: 149°-152° C.

Provenance & Evidence