Traboxopine → HCID 14555943, compound

Participants

Reaction Steps

34.7 g (0.10 moles) of racemic 2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine are dissolved in 165 CM3 of dichloromethane, and 15.0 g (0.10 moles of L(+)-tartaric acid are added to the solution obtained under stirring. The mixture is further stirred for 10 to 12 hours at room temperature. The (+)-base L(+)-tartrate precipitated is filtered and dried. Thus, 15.8 g (63.7%) of (+)-2-Chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine L(+)-tartrate are obtained, m.p.: 148°-150° C.

Provenance & Evidence