Traboxopine → HCID 14555943, compound

Participants

Reaction Steps

From the dichloromethane filtrate obtained in Example 3, section (A), the base is deliberated by the method of Example 1, section (B). To the residual syrup weighing 21.5 g, 9.3 g 0.063 moles of L(+)-tartaric acid are added in 85 CM3 of water. At first, a solution is obtained that is stirred for several hours. The (-)-base L(+)-tartrate precipitated is filtered, suspended in cold water, then filtered, suspended and filtered again. Thus, 17.5 g (70.0%) of (-)-2-chloro-12-(3-dimethylamino-2-methylpropyl)-12H-dibenzo[d,g][1,3,6]dioxazocine L(+)-tartrate are obtained, m.p.: 109°-114° C.

Provenance & Evidence