反应详情

3,4-Dihydro-3-methyl-2(1H)-quinazolinone (2.5 g) is added to a stirred suspension of anhydrous aluminum chloride (10.5 g) in carbon disulfide (120 ml) under nitrogen. 3-Carbomethoxy-2-methyl-propionyl chloride (2.5 g) is added dropwise to the stirred suspension, which is refluxed for about 18 hours and cooled to RT. The liquid phase is decanted and the residue treated with H2O (120 ml) and extracted with methylene chloride. The organic extract is dried, filtered and concentrated in vacuo, affording the desired product as a solid, which is used in the next step without further purification.

1. temperatureis refluxed for about 18 hours
2. customThe liquid phase is decanted
3. additionthe residue treated with H2O (120 ml)
4. extractionextracted with methylene chloride
5. extractionThe organic extract
6. customis dried
7. filtrationfiltered
8. concentrationconcentrated in vacuo