HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(4-Fluorobenzoyl)butanoic acid | HCID 12449524 | — |
| Reactant | HCID 178418642 | HCID 178418642 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid | HCID 9947748 | — |
Reaction Steps
A solution of 3-(4-fluorobenzoyl)butanoic acid (8 g), 4-hydroxypyridine (8 g) and sodium hydroxide (4.6 g) in water (80 ml) was heated in an autoclave at 140° C. for 20 hours. The reaction mixture was cooled and on acidification to pH3 with dilute hydrochloric acid afforded as a white crystalline precipitate 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid, 9.45 g, m.p. 250°-252° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04906628 |
| Source dataset | uspto-grants-1990_03 |
| ORD ID | ord-ffb9d8b09d9e461ebbca96563222b5c0 |
| Source note | uspto-grants-1990_03 |