Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylethylenediamine → 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylethylenediamine | HCID 8014 | — |
| 반응물 | (3,5-diamino-6-chloropyrazin-2-yl)(1H-imidazol-1-yl)methanone | HCID 13020010 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide | HCID 19861822 | 85% |
반응 단계
A mixture of 24.0 g (100.0 mmol) of 1-(3,5-diamino-6-chloropyrazinoyl)imidazole (see U.S. Pat. No. 4,029,816 as an example of how to obtain this material) and 13.6l g (183.5 mmol) of N-methylethylenediamine in 100 ml of tetrahydrofuran was stirred at ambient temperature for 18 hours. The reaction mixture was filtered and evaporated. The residue was crystallized from 2-propanol to give 20.8 g (85.0 mmol, 85%) of 3,5-diamino-6-chloro-N-(2-methylaminoethyl)pyrazine-2-carboxamide; mp 142.5°-143° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04906633 |
| 출처 데이터셋 | uspto-grants-1990_03 |
| ORD ID | ord-b912c3cef26242b6b9b679f1c6c03318 |
| 출처 메모 | uspto-grants-1990_03 |